1. I-CARE was borne for the pioneering efforts of its founders in spreading the science of alternatives to the use of animals in India and Italy. “The Science of Alternatives - movement” in India through I-CARE promoted the universal concept of 3Rs (Replacement, Reduction and Refinement) in the use of animals in research and education and testing under the aegis of CPCSEA, GOI and otherwise as its main focus and mission from 2000. The work of the founders on the concept of Ahimsa and Alternatives has been published in several peer reviewed international journals like ALTEX and presented in International conferences / congress.

2. Initiated the rescue and rehabilitation of thousands of laboratory animals from the year 2000 which were subject to cruel experiments in laboratories that included dog s, horses and primates across India. And continues to do so.We have been responsible for coining the term called 4Th R – Rehabilitation.

3. We have been responsible for coining the term called 4Th R – Rehabilitation of laboratory animals as a continuum of the universal 3R concept of Russel and Burch and this has become an official policy of the CPCSEA, GOI. from 2004, where by hundreds of beagles continue to be rehabilitated from laboratories to loving homes to date.

4. Initiated a national movement in 2007 amongst teachers and students in India to stop the use of animals in dissection. This resulted in University Grants Commission, Govt. Of India, finally issuing orders to ban dissection of animals in life sciences in 2012, saving the lives of over 18 million animals every year.

5. Organized the First Indian National Congress on Alternatives to the use of Animals in Research , Testing and Education in January 2007 at Sri Ramachandra University , Chennai which included real time workshops conducted by L’Oreal, Skin ETHIC etc.

6. Initiated and developed the National Guidelines for the rehabilitation and reuse of dogs- first of its kind in the world - in 2014 as a member of the CPCSEA. India is now the first ever country in the world to have developed guidelines to limit the years of use and confinement for dogs in a laboratory. Hundreds of beagles have been released and continue to be released from laboratories to homes where they enjoy the bliss of freedom and love for the first time in their lives.

7. Founded the Mahatma Gandhi Doerenkamp Centre for Alternatives to the use of Animals in Research and Education in the Bharathidasan University, Trichy in 2009. It is the first and only such center in Asia, The center trains students /scientists ‘in- vitro’ (non – animal) methods in research/teaching. In February 2016 it was declared as the National Centre for Alternatives to Animal Experiments” under the University Grants Commission, Govt. Of India.

8. Launched the ‘SOUND OF SILENCE’ (S.O.S) Campaign at IIT Mumbai, at Techfest 2016 with GUL PANAG – amidst thousands of students who had gathered from across India.
The S.O.S campaign aimed at bringing awareness to the silent suffering of dogs used in toxicity testing and with the goal to one day stop all use of dogs in toxicity testing. The campaign has also over 130,000 supporters on change.org.

9. In October 2017 and again in May 2018, successfully organized two National Round Table Conferences which included participants from regulatory depts in the GOI, testing laboratories and animal welfare organizations for the first time in India. The participants after long deliberations and it was indeed a historic moment at the first Round Table Conference held at NAARM, Hyderabad, when the participants agreed in unison and recommended that in view of the recent scientific findings that the dog is a deeply sentient being and must be urgently replaced in the use of testing.

10. Founded Project D.O.N.T (Dogs are Not for Testing) in 2017- D.O.N.T. is a project that seeks to augment the precision and prediction of drug/ chemical toxicity by replacing the dog in testing with the power and potential of machine learning and Artificial/Augmented Intelligence. Project D.O.N.T has been selected as a project by IBM (USA) Corporate Citizenship program in 2019 and adopted by IBM’s “Science for Social Good” Deep learning group of researchers working at the IBM Watson Research Center , New York. The publication of which is now with NATURE Scientific on the deep learning model developed to predict toxicity precisely and thereby to replace animals in drug discovery and agro- chemical testing.